Summer School and Workshop

June 3 - 8, 2023

Hotel Balkan / Sofia, Bulgaria

Recent years have seen an explosion of interest in understanding 3D genome architecture and dynamics in living cells and their implications for biological function. This has been made possible by the advent of technologies that provide unprecedented information regarding the spatial organization of genomes, their variations between cell types and species, and their temporal dynamics. This, in turn, has led to a flowering of theories, combining concepts from molecular biophysics, polymer science, and machine learning to create quantitatively accurate frameworks for confronting hypothesized mechanisms with experimental observations.

This meeting will bring together pioneers in the aforementioned developments to discuss the most recent advances including novel imaging and advanced contact-mapping modalities, the role of condensates in biological function, loop extrusion and others molecular motor driven processes, etc. The meeting will also bring together researchers to address fundamental questions on the two-way relationships between chromosome structure and function. These functions include control of transcription (e. g. in the context of development), DNA damage repair, DNA replication, and genome evolution. The goal is to develop a shared blueprint for how the field can move forward and address the most compelling challenges over the next few years.

Advisory Board

  • Genevieve Almouzni

    Genevieve Almouzni

    Institut Curie, Paris

  • Arup Chakraborty

    Arup Chakraborty

    MIT, Boston

  • Ibrahim Cisse

    Ibrahim Cisse

    Max Planck Institute of Immunobiology and Epigenetics, Freiburg

  • Antoine Coulon

    Antoine Coulon

    Institut Curie, Paris

  • Stefan Dimitrov

    Stefan Dimitrov

    Institute of Molecular Biology, Sofia

  • William C. Earnshaw

    William C. Earnshaw

    University of Edinburgh, Edinburgh

  • Anastas Gospodinov

    Anastas Gospodinov

    Institute of Molecular Biology, Sofia

  • Taekjip Ha

    Taekjip Ha

    Johns Hopkins University, Baltimore

  • Herbert Levine

    Herbert Levine

    Northeastern University, Boston

  • Leonid Mirny

    Leonid Mirny

    MIT, Boston

  • Jose’ Onuchic

    Jose’ Onuchic

    Rice University, Houston

  • Rohit Pappu

    Rohit Pappu

    University of Washington,

  • Benjamin Rowland

    Benjamin Rowland

    Netherlands Cancer Institute, Amsterdam

  • Phillip Sharp

    Phillip Sharp

    MIT, Boston

  • Stoyno S. Stoynov

    Stoyno S. Stoynov

    Institute of Molecular Biology, Sofia

  • Angela Taddei

    Angela Taddei

    Institut Curie, Paris

  • Iva Ugrinova

    Iva Ugrinova

    Institute of Molecular Biology, Sofia

  • Richard Young

    Richard Young

    MIT, Boston

Organizing Committee

  • Antoine Coulon, Institut Curie, Paris
  • Anastas Gospodinov, Institute of Molecular Biology, Sofia
  • Herbert Levine, Northeastern University, Boston
  • Jose’ Onuchic, Rice University, Houston
  • Stoyno S. Stoynov, Institute of Molecular Biology, Sofia
  • Angela Taddei, Institut Curie, Paris